ENERGY SUBSTRATE IS KEY
In the resting state, BRAIN, HEART, LIVER, and KIDNEYS consume the majority of available energy. See: Berg JM, Tymoczko JL, and Stryer L. Biochemistry, 5th ed. New York: WH Freeman, 2002, Section 30.2 “EACH ORGAN HAS A UNIQUE METABOLIC PROFILE: FATTY ACIDS ARE THE HEART’S MAIN SOURCE OF FUEL; ALPHA KETO-ACIDS DERIVED FROM THE DEGRADATION OF AMINO […]
AVOIDING CHRONIC LOW-GRADE METABOLIC ACIDOSIS
Modern Western diets, in general, and ketogenic diets, in particular, are thought to produce a chronic low-grade metabolic acidosis. Buffering capability may be supported in the following ways: Avoid, when approved by the treating neurologist, anti-convulsant drugs that may interfere with acid/base (pH) homeostasis: valproate (Depakote; Depakene; Epilim; Epival and other brand names); carbonic anhydrase […]
BETA – OXIDATION
Measures protective of mitochondrial and peroxisomal Beta-Oxidation in High Fat Ketogenic Diets
Nutrient-dense Modified Ketogenic Diet
The majority of calories is derived from ghee (clarified butter), dairy cream, and pure soured cream (crème fraîche) that provide, and help metabolize, the fat soluble vitamins A, D, E, and K. Pastured eggs, meat, and fresh fish provide nutrition of complex biological value. Greens provide vitamins, minerals, phytonutrients, anti-oxidants, and fiber. One lemon or lime […]
MODIFIED KETOGENIC DIET BASED ON THE FATTY ACID COMPOSITION OF HUMAN MILK
Ketogenic diet (KD), a proven treatment for epilepsy, is of interest in mitochondrial and peroxisomal (cellular energy) research. Fat provides up to 90% of calories in KD, yet there is no scientific consensus as to how fatty acids (the constituents of fat) might be exploited to improve efficacy. The composition of fatty acids in cow’s milk closely […]
Case History
Poster presented at the 2nd International Symposium on Dietary Therapies for Epilepsy and other Neurological Disorders, Edinburgh, Oct 2010 View pdf: EdinburghposterFinal Refractory epilepsy controlled by an acidosis sparing, euketonemic ketogenic (ASEK) diet: a case history. A.W.C. Yuen¹, I.A. Walcutt². Introduction Classical ketogenic diet, the modified Atkins diet and other variants generally produce hyperketonemia (2 – 6 mM/L of […]